Cape St. Mary's is located at the southwestern tip of Newfoundland's Avalon Peninsula. It's a two-and-a-half hour drive from St. John's (Trans-Canada Highway/Route 1 to the Cape Shore highway/Route 90), and about an hour from Argentia/Placentia.
The turnoff to the reserve access road is about 15 km east of St. Bride's and 15 km west of Branch.
The path to Bird Rock is not wheelchair accessible, but the Interpretive Centre is fully accessible.
Aircraft are prohibited from landing in the reserve, or flying lower than 300 metres from April 1 to October 30. No tankers or vessels longer than 20 metres are permitted in the marine portion of the reserve.