The community of Fortune is about 210 km down Newfoundland's Burin Peninsula highway (Route 210) from the Trans-Canada Highway's Goobies turnoff. The reserve is about 1.6 km to the west of Fortune, along Route 220.
Access to the cliffs at Fortune Head is by foot. Access to the reserve can be gained by driving a maintained gravel road that leads to Fortune Head light station, a navigational aid operated by the Canadian Coast Guard. Visitors can walk from the lighthouse parking area to explore the reserve.
ATV use is prohibited in the reserve.