Scientific research, hunting and fishing, and outfitting are the main activities that take place in the reserve. For more information and research guidelines, see Science & Research.
All-terrain vehicles (ATVs) are not allowed in the reserve, even for game retrieval.
Hunting and fishing are permitted in the reserve, in the appropriate seasons and with valid licences. Trapping and small game snaring is prohibited in the Little Grand Lake Provisional Ecological Reserve.
Snowmobiling, using motorized boats, and landing a plane or helicopter is permitted.