The communities near the Witless Bay Ecological Reserve are a half-hour to 45 minute drive (about 30 km) south from St. John's, Newfoundland, along Route 10, the Irish Loop Drive. You can also drive from the Trans-Canada Highway (Route 1) and take the Witless Bay Line (Route 13) to the Irish Loop Drive (Route 10).
Commercial tour-boat operators exist in many of the communities near the islands. For more information, see Services.
Aircraft are prohibited from landing in the reserve, or flying lower than 300 metres, from April 1 to September 1. No tankers or vessels longer than 20 metres are permitted in the marine portion of the reserve.