Located in the southeastern portion of central Newfoundland, the Bay du Nord Wilderness Reserve is flanked by three main highways. To its north is the Trans-Canada, to the west Route 360 (extending from Bishop's Falls to Harbour Breton), and to the east Route 210 (the Burin Peninsula highway).
Entry permits are required to visit the reserve. Access to the reserve is by hiking, snowmobile, boat, or aircraft. No all-terrain vehicles are permitted in the reserve. Note that snowmobiling is not permitted in the caribou winter range from December 15 to March 15, and aircraft require a permit to land. See Bay du Nord Wilderness Reserve User's Guide for a map of the winter range of the caribou herd.
Hikers can access the reserve from trails that run off Route 360: one is 12 km north of Jipujijkuei Kuespem Provincial Park and leads to the edge of the Middle Ridge Wildlife Reserve; the other is 4.5 km south of the park and leads to a transmission line that enters the reserve below Medonnegonik and Koskaecodde Lakes and continues along much of the southern boundary of the reserve. From the east, the best way in is from Piper's Hole River. Here, hikers can follow a transmission line right-of-way which leaves near the river and tracks west along the southern boundary of the reserve. These trails and transmission lines are marked on the topographical maps of the area.
As described above, a transmission line leads west from the Piper's Hole River to the Bay d'Espoir highway, following much of the reserve's southern boundary. Newfoundland Hydro personnel use an access road from the Bay d'Espoir highway to reach the section of transmission line within the reserve. Motorized vehicle use of the portion of the transmission line trail in the reserve is restricted to Newfoundland Hydro personnel.
Canoeists can paddle into the reserve from Kepenkek Lake (near the reserve's northern boundary). This lake is reached by a rough woods road from route 301 in Terra Nova National Park, or by air.
Float plane and helicopter access is possible, but you must have an entry permit. While over the reserve, aircraft must not be flown at altitudes lower than 600 metres, except during landing and take-off.